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human kidney proximal tubule epithelial hk-2 cells  (BioResource International Inc)

 
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    BioResource International Inc human kidney proximal tubule epithelial hk-2 cells
    Human Kidney Proximal Tubule Epithelial Hk 2 Cells, supplied by BioResource International Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human kidney proximal tubule epithelial hk-2 cells/product/BioResource International Inc
    Average 90 stars, based on 1 article reviews
    human kidney proximal tubule epithelial hk-2 cells - by Bioz Stars, 2026-03
    90/100 stars

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    STAP2 regulates the advancement of renal fibrosis through the HSP27-PI3K/AKT signaling pathway. After various factors lead to renal injury, the upregulation of STAP2 promotes the interaction between STAP2 and HSP27, further enhancing the phosphorylation of HSP27 and activation of the PI3K/AKT signaling pathway, which results in the loss of epithelial phenotype in epithelial cells, activation of fibroblasts and ultimately results in renal interstitial fibrosis

    Journal: Journal of Translational Medicine

    Article Title: STAP2 promotes the progression of renal fibrosis via HSP27

    doi: 10.1186/s12967-024-05776-6

    Figure Lengend Snippet: STAP2 regulates the advancement of renal fibrosis through the HSP27-PI3K/AKT signaling pathway. After various factors lead to renal injury, the upregulation of STAP2 promotes the interaction between STAP2 and HSP27, further enhancing the phosphorylation of HSP27 and activation of the PI3K/AKT signaling pathway, which results in the loss of epithelial phenotype in epithelial cells, activation of fibroblasts and ultimately results in renal interstitial fibrosis

    Article Snippet: The China Center for Type Culture Collection (Wuhan, China) provided the normal human kidney proximal tubule epithelial cell line (HK-2), which was grown in a DMEM/F12 medium (#G4610-500ML, Servicebio, Wuhan, China) supplemented with 10% fetal bovine serum (FBS, Gibco, USA).

    Techniques: Phospho-proteomics, Activation Assay